Interactomes, manufacturomes and relational biology: analogies between systems biology and manufacturing systems

• Main Authors: Rietman Edward A, Colt John Z, Tuszynski Jack A
• Format: Article
• Language: English
• Published: BMC 2011-06-01
• Series: Theoretical Biology and Medical Modelling
• Online Access: http://www.tbiomed.com/content/8/1/19

<p>Abstract</p> <p>Background</p> <p>We review and extend the work of Rosen and Casti who discuss category theory with regards to systems biology and manufacturing systems, respectively.</p> <p>Results</p> <p>We describe anticipatory systems, or long-range feed-forward chemical reaction chains, and compare them to open-loop manufacturing processes. We then close the loop by discussing metabolism-repair systems and describe the rationality of the self-referential equation <it>f </it>= <it>f </it>(<it>f</it>). This relationship is derived from some boundary conditions that, in molecular systems biology, can be stated as the cardinality of the following molecular sets must be about equal: metabolome, genome, proteome. We show that this conjecture is not likely correct so the problem of self-referential mappings for describing the boundary between living and nonliving systems remains an open question. We calculate a lower and upper bound for the number of edges in the molecular interaction network (the interactome) for two cellular organisms and for two manufacturomes for CMOS integrated circuit manufacturing.</p> <p>Conclusions</p> <p>We show that the relevant mapping relations may not be Abelian, and that these problems cannot yet be resolved because the interactomes and manufacturomes are incomplete.</p>