ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln<sup>347</sup>, Gln<sup>725</sup>, Gln<sup>990</sup> to Confer Cellular Resistance to the Anticancer Drug Taxol

ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln<sup>347</sup>, Gln<sup>725</sup>, Gln<sup>990</sup> to Confer Cellular Resistance to the Anticancer Drug Taxol

The multidrug efflux transporter ABCB1 is clinically important for drug absorption and distribution and can be a determinant of chemotherapy failure. Recent structure data shows that three glutamines donate hydrogen bonds to coordinate taxol in the drug binding pocket. This is consistent with earlie...

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Bibliographic Details
Main Authors: Keerthana Sasitharan, Hamzah Asad Iqbal, Foteini Bifsa, Aleksandra Olszewska, Kenneth J. Linton
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
P-glycoprotein
multidrug resistance
ABCB1
taxol
drug transport
ABC transporter
Online Access:https://www.mdpi.com/1422-0067/22/16/8561

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