Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->

Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->

Two new compounds, named lyciumlignan D (1) and lyciumphenyl propanoid A (2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those o...

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Main Authors: Yanan Yang, Yawen An, Wei Wang, Ning Du, Jinghua Zhang, Ziming Feng, Jianshuang Jiang, Peicheng Zhang
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lycium chinense
Lyciumlignan D
Lyciumphenyl propanoid A
Structure elucidation
Anti-inflammatory effect
Online Access:http://www.sciencedirect.com/science/article/pii/S221138351730076X
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spelling doaj-d9cbdf73de7e4b139702369e8bb163642020-11-24T23:18:48ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432017-07-017449149510.1016/j.apsb.2017.04.004Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->Yanan Yang0Yawen An1Wei Wang2Ning Du3Jinghua Zhang4Ziming Feng5Jianshuang Jiang6Peicheng Zhang7State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaBeijing Centre for Physical and Chemical Analysis, Beijing 100089, ChinaBeijing Centre for Physical and Chemical Analysis, Beijing 100089, ChinaBeijing Centre for Physical and Chemical Analysis, Beijing 100089, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaTwo new compounds, named lyciumlignan D (1) and lyciumphenyl propanoid A (2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 39 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.http://www.sciencedirect.com/science/article/pii/S221138351730076XLycium chinenseLyciumlignan DLyciumphenyl propanoid AStructure elucidationAnti-inflammatory effect
collection DOAJ
language English
format Article
sources DOAJ
author Yanan Yang
Yawen An
Wei Wang
Ning Du
Jinghua Zhang
Ziming Feng
Jianshuang Jiang
Peicheng Zhang
spellingShingle Yanan Yang
Yawen An
Wei Wang
Ning Du
Jinghua Zhang
Ziming Feng
Jianshuang Jiang
Peicheng Zhang
Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
Acta Pharmaceutica Sinica B
Lycium chinense
Lyciumlignan D
Lyciumphenyl propanoid A
Structure elucidation
Anti-inflammatory effect
author_facet Yanan Yang
Yawen An
Wei Wang
Ning Du
Jinghua Zhang
Ziming Feng
Jianshuang Jiang
Peicheng Zhang
author_sort Yanan Yang
title Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
title_short Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
title_full Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
title_fullStr Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
title_full_unstemmed Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
title_sort nine compounds from the root bark of lycium chinense and their anti-inflammatory activitieslammatory activitiesretain-->
publisher Elsevier
series Acta Pharmaceutica Sinica B
issn 2211-3835
2211-3843
publishDate 2017-07-01
description Two new compounds, named lyciumlignan D (1) and lyciumphenyl propanoid A (2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 39 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.
topic Lycium chinense
Lyciumlignan D
Lyciumphenyl propanoid A
Structure elucidation
Anti-inflammatory effect
url http://www.sciencedirect.com/science/article/pii/S221138351730076X
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