The splicing factor ASF/SF2 and intron retention as markers of endothelial senescence

Aging is the major risk factor per se for the development of cardiovascular diseases. The senescence of endothelial cells, that line the lumen of blood vessels, is at the cellular basis of these age-dependent vascular pathologies, including atherosclerosis and hypertension. Along their lifespan, end...

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Bibliographic Details
Main Authors: Francisco Javier Blanco, Carmelo eBernabeu
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-03-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00054/full