Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound.

Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound.

We have previously reported the inhibition of bacterial topoisomerase I activity by a fluoroquinophenoxazine compound (FP-11g) with a 6-bipiperidinyl lipophilic side chain that exhibited promising antituberculosis activity (MIC = 2.5 μM against Mycobacterium tuberculosis, SI = 9.8). Here, we found t...

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Bibliographic Details
Main Authors: Pamela K Garcia, Thirunavukkarasu Annamalai, Wenjie Wang, Raven S Bell, Duc Le, Paula Martin Pancorbo, Sabah Sikandar, Ahmed Seddek, Xufen Yu, Dianqing Sun, Anne-Catrin Uhlemann, Purushottam B Tiwari, Fenfei Leng, Yuk-Ching Tse-Dinh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0207733

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