Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation

Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation

Abstract Background Uric acid (UA) plays important roles in inducing renal inflammation, intra-renal vasoconstriction and renal damage. Endothelin-1 (ET-1) is a well-known profibrotic factor in the kidney and is associated with fibroblast expansion. We examined the role of hyperuricemia conditions i...

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Bibliographic Details
Main Authors: Muhammad Mansyur Romi, Nur Arfian, Untung Tranggono, Wiwit Ananda Wahyu Setyaningsih, Dwi Cahyani Ratna Sari
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Nephrology
Subjects:
Hyperuricemia
ET-1
Glomerulosclerosis
Tubular injury
Fibroblast expansion
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12882-017-0736-x

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