Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages

Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages

Abstract. Background Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influence cancer progression and patient survival. Extracellular vesicles (EV...

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Bibliographic Details
Main Authors: Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē, Una Riekstiņa
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Cell Communication and Signaling
Subjects:
Extracellular vesicles
cytokines
endocytosis
monocytes
macrophages
colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12964-018-0229-y

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