Adipose tissue stem cells in sinus lift procedures and the use of a combination of bone marrow stem cells, blood derived growth factors and allograft for the augmentation of the severely resorbed maxilla

• Main Authors: MS Maningky, Tymour Forouzanfar, Engelbert A.J.M Schulten
• Format: Article
• Language: English
• Published: Hasanuddin University 2016-06-01
• Series: Journal of Dentomaxillofacial Science
• Subjects: Stem cells, Growth factors, Allograft, Maxilla
• Online Access: http://jdmfs.org/index.php/jdmfs/article/view/35
• ISSN: 2503-0817; 2503-0825

For smaller bone grafts combining bone substitutes with blood derived growth factors such as PRP and PRF leads to good results.However for the treatment of the extremely resorbed edentulous maxilla prior to implant placement, autogenous bone remains the gold standard. Due to the challenging grafts in often older medically compromised patients the use of bone substitutes alone is not as predictable as autogenous bone.Although autogenous bone is the gold standard the use of block grafts from the iliac crest is associated with significant donorsite morbidity.The use of stem cells and growth factors combined with bone substitute is a promising development which might ultimately replace the need for autogenous bone.Our clinic has done a lot of research in using adipose tissue stem cells in sinus lift procedures, the results will be presented here.We will also present our clinical results of using a combination of bone substitutes with bone marrow stem cells and blood derived growth factors in treating the extremely resorbed edentulous maxilla. Focusing on the difference between adipose tissue stem cells bone marrow and the rationale, surgical considerations and the rationale for combining bone marrow stem cells with blood derived growth factors.