Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model

Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model

Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. Here, we identified tranylcypromine, which is used to...

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Bibliographic Details
Main Authors: Jing Huang, Fangkun Liu, Hui Tang, Haishan Wu, Lehua Li, Renrong Wu, Jingping Zhao, Ying Wu, Zhixiong Liu, Jindong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Neurology
Subjects:
cerebral organoids
tranylcypromine
neurotoxicity
in vitro models
neuropsychiatric disease
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00626/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2017.00626/full

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