Sex specific correlation between GABAergic disruption in the dorsal hippocampus and flurothyl seizure susceptibility after neonatal hypoxic-ischemic brain injury

Sex specific correlation between GABAergic disruption in the dorsal hippocampus and flurothyl seizure susceptibility after neonatal hypoxic-ischemic brain injury

Since neonatal hypoxia-ischemia (HI) disrupts the hippocampal (Hp) GABAergic network in the mouse and Hp injury in this model correlates with flurothyl seizure susceptibility only in male mice, we hypothesized that GABAergic disruption correlates with flurothyl seizure susceptibility in a sex-specif...

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Bibliographic Details
Main Authors: Charles R. Lechner, Melanie A. McNally, Mark St. Pierre, Ryan J. Felling, Frances J. Northington, Carl E. Stafstrom, Raul Chavez-Valdez
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
GABA receptor
Neonatal seizure
Parvalbumin
Sex-dimorphism
Somatostatin
Neonatal brain injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304976

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http://www.sciencedirect.com/science/article/pii/S0969996120304976

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