Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites

Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites

There has been growing interest in utilizing small interfering RNA (siRNA) specific to pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), in chronic inflammation therapy. However, delivery systems that can increase the distribution of the siRNA in chronic inflammation sites after i...

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Bibliographic Details
Main Authors: Abdulaziz M Aldayel, Youssef W Naguib, Hannah L O'Mary, Xu Li, Mengmeng Niu, Tinashe B Ruwona, Zhengrong Cui
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Endo-lysosomal escape
inhibition of TNF-α release
LPS-induced chronic inflammation
macrophage uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300550

Internet

http://www.sciencedirect.com/science/article/pii/S2162253117300550

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