(2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues

(2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues

Efficient and scalable syntheses of enantiomerically pure (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl]alanines 9a–c, as well as allo-D-threonine (4) and (2S,3R)-β-methylphenylalanine (3), using the Belokon' approach with (S)- and (R)-2-[(N-benzylp...

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Bibliographic Details
Main Authors: Armin de Meijere, Sergei I. Kozhushkov, Dmitrii S. Yufit, Christian Grosse, Marcel Kaiser, Vitaly A. Raev
Format: Article
Language:English
Published: Beilstein-Institut 2014-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amino acids
biosynthesis
building blocks
cyclopropanes
natural products
synthetic methods
Online Access:https://doi.org/10.3762/bjoc.10.302

Internet

https://doi.org/10.3762/bjoc.10.302

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