Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: Relevance to schizophrenia

Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: Relevance to schizophrenia

Glutathione (GSH) metabolism dysfunction is one risk factor in schizophrenia. A transitory brain GSH deficit was induced in Wistar (WIS) and mutant (ODS; lacking ascorbic acid synthesis) rats using BSO (l-buthionine-(S,R)-sulfoximine) from post-natal days 5–16. When GSH was re-established to physiol...

Full description

Bibliographic Details
Main Authors: Jan-Harry Cabungcal, Delphine Preissmann, Caroline Delseth, Michel Cuénod, Kim Q. Do, Françoise Schenk
Format: Article
Language:English
Published: Elsevier 2007-06-01
Series:Neurobiology of Disease
Subjects:
Cognitive impairment
Development, l-buthionine-(S,R)-sulfoximine (BSO)
Glutathione (GSH)
Oxidative stress
Olfactory discrimination
Place discrimination
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000599

Internet

http://www.sciencedirect.com/science/article/pii/S0969996107000599

Similar Items