Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel

Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel

Nanosponges (NS) of etodolac(ETO) was prepared using the emulsion solvent diffusion method ; the effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and character...

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Main Authors: Maysam M. Abass, Nawal A. Rajab
Format: Article
Language:English
Published: College of Pharmacy University of Baghdad 2019-06-01
Series:Iraqi Journal of Pharmaceutical Sciences
Online Access:http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/824
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spelling doaj-d9795b781fe24e30bc3e5b53b4ac37bf2020-11-25T01:01:27ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972019-06-01281647410.31351/vol28iss1pp64-74824Preparation and Characterization of Etodolac as a Topical Nanosponges HydrogelMaysam M. Abass0Nawal A. Rajabbaghdad college of pharmacyNanosponges (NS) of etodolac(ETO) was prepared using the emulsion solvent diffusion method ; the effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and characterized, The selected formula was lyophilized then incorporated into hydrogel ; which also evaluated .The results show that the formulation that contain Drug: PVA:EC in ratio 1:3:2 is the best with smallest particle size 40.2±0.098 with polydispersibility0.005 and in vitro release 97.6±0.11%, , ETO NS Carbopol hydrogel produced a significant(p<0.05) improvement of the in vitro release than pure ETO hydrogel.http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/824
collection DOAJ
language English
format Article
sources DOAJ
author Maysam M. Abass
Nawal A. Rajab
spellingShingle Maysam M. Abass
Nawal A. Rajab
Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel
Iraqi Journal of Pharmaceutical Sciences
author_facet Maysam M. Abass
Nawal A. Rajab
author_sort Maysam M. Abass
title Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel
title_short Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel
title_full Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel
title_fullStr Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel
title_full_unstemmed Preparation and Characterization of Etodolac as a Topical Nanosponges Hydrogel
title_sort preparation and characterization of etodolac as a topical nanosponges hydrogel
publisher College of Pharmacy University of Baghdad
series Iraqi Journal of Pharmaceutical Sciences
issn 2521-3512
1683-3597
publishDate 2019-06-01
description Nanosponges (NS) of etodolac(ETO) was prepared using the emulsion solvent diffusion method ; the effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and characterized, The selected formula was lyophilized then incorporated into hydrogel ; which also evaluated .The results show that the formulation that contain Drug: PVA:EC in ratio 1:3:2 is the best with smallest particle size 40.2±0.098 with polydispersibility0.005 and in vitro release 97.6±0.11%, , ETO NS Carbopol hydrogel produced a significant(p<0.05) improvement of the in vitro release than pure ETO hydrogel.
url http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/824
work_keys_str_mv AT maysammabass preparationandcharacterizationofetodolacasatopicalnanospongeshydrogel
AT nawalarajab preparationandcharacterizationofetodolacasatopicalnanospongeshydrogel
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