The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice

The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice

A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modifie...

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Main Authors: Lijuan Chen, Xin Yan, Qianlin Yan, Jiajun Fan, Hai Huang, Xunlong Shi, Lei Han, Tianxiong Han, Haiyan Zhu
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2015/790739
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spelling doaj-d97841781573430d846318e0cd7a1cff2020-11-24T21:15:13ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/790739790739The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in MiceLijuan Chen0Xin Yan1Qianlin Yan2Jiajun Fan3Hai Huang4Xunlong Shi5Lei Han6Tianxiong Han7Haiyan Zhu8Department of Chinese Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, ChinaInstitute of Chinese Medicine, Tongji University School of Medicine, Shanghai 200092, ChinaDepartment of Chinese Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, ChinaDepartment of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, ChinaDepartment of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, ChinaDepartment of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, ChinaDepartment of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, ChinaDepartment of Chinese Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, ChinaDepartment of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, ChinaA new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.http://dx.doi.org/10.1155/2015/790739
collection DOAJ
language English
format Article
sources DOAJ
author Lijuan Chen
Xin Yan
Qianlin Yan
Jiajun Fan
Hai Huang
Xunlong Shi
Lei Han
Tianxiong Han
Haiyan Zhu
spellingShingle Lijuan Chen
Xin Yan
Qianlin Yan
Jiajun Fan
Hai Huang
Xunlong Shi
Lei Han
Tianxiong Han
Haiyan Zhu
The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
Evidence-Based Complementary and Alternative Medicine
author_facet Lijuan Chen
Xin Yan
Qianlin Yan
Jiajun Fan
Hai Huang
Xunlong Shi
Lei Han
Tianxiong Han
Haiyan Zhu
author_sort Lijuan Chen
title The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
title_short The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
title_full The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
title_fullStr The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
title_full_unstemmed The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice
title_sort modified jiuwei qianghuo decoction alleviated severe lung injury induced by h1n1 influenza virus by regulating the nf-κb pathway in mice
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2015-01-01
description A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.
url http://dx.doi.org/10.1155/2015/790739
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