Efflux-mediated fluoroquinolone resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7: identification of a novel MexS variant involved in upregulation of the mexEF-oprN multidrug efflux operon

Efflux-mediated fluoroquinolone resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7: identification of a novel MexS variant involved in upregulation of the mexEF-oprN multidrug efflux operon

The emergence of multidrug-resistant Pseudomonas aeruginosa has become a serious problem in medical settings. P. aeruginosa clinical isolate PA7 is resistant to fluoroquinolones, aminoglycosides, and most -lactams but not imipenem. In this study, enhanced efflux-mediated fluoroquinolone resistance...

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Bibliographic Details
Main Authors: Yuji eMorita, Junko eTomida, Yoshiaki eKawamura
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
efflux
mexXY-oprA
mexEF-oprN
mexS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00008/full

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