Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
Cation-proton antiporters mediate selective ion exchange across cellular membranes to control pH, salt concentration and cell volume. Here the authors present a transition-path sampling method that overcomes the timescale gap between simulations (µs) and transport processes (s), which allows them to...
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2019-04-01
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Online Access: | https://doi.org/10.1038/s41467-019-09739-0 |
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doaj-d96f57b101b645f8954b444ea2b082fa2021-05-11T12:00:27ZengNature Publishing GroupNature Communications2041-17232019-04-0110111010.1038/s41467-019-09739-0Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shootingKei-ichi Okazaki0David Wöhlert1Judith Warnau2Hendrik Jung3Özkan Yildiz4Werner Kühlbrandt5Gerhard Hummer6Department of Theoretical and Computational Molecular Science, Institute for Molecular Science, National Institutes of Natural SciencesDepartment of Structural Biology, Max Planck Institute of BiophysicsDepartment of Theoretical Biophysics, Max Planck Institute of BiophysicsDepartment of Theoretical Biophysics, Max Planck Institute of BiophysicsDepartment of Structural Biology, Max Planck Institute of BiophysicsDepartment of Structural Biology, Max Planck Institute of BiophysicsDepartment of Theoretical Biophysics, Max Planck Institute of BiophysicsCation-proton antiporters mediate selective ion exchange across cellular membranes to control pH, salt concentration and cell volume. Here the authors present a transition-path sampling method that overcomes the timescale gap between simulations (µs) and transport processes (s), which allows them to resolve the Na+ and H+ transport cycle of the Na+/H+ antiporter NhaP from Pyrococcus abyssi.https://doi.org/10.1038/s41467-019-09739-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kei-ichi Okazaki David Wöhlert Judith Warnau Hendrik Jung Özkan Yildiz Werner Kühlbrandt Gerhard Hummer |
spellingShingle |
Kei-ichi Okazaki David Wöhlert Judith Warnau Hendrik Jung Özkan Yildiz Werner Kühlbrandt Gerhard Hummer Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting Nature Communications |
author_facet |
Kei-ichi Okazaki David Wöhlert Judith Warnau Hendrik Jung Özkan Yildiz Werner Kühlbrandt Gerhard Hummer |
author_sort |
Kei-ichi Okazaki |
title |
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting |
title_short |
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting |
title_full |
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting |
title_fullStr |
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting |
title_full_unstemmed |
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting |
title_sort |
mechanism of the electroneutral sodium/proton antiporter panhap from transition-path shooting |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-04-01 |
description |
Cation-proton antiporters mediate selective ion exchange across cellular membranes to control pH, salt concentration and cell volume. Here the authors present a transition-path sampling method that overcomes the timescale gap between simulations (µs) and transport processes (s), which allows them to resolve the Na+ and H+ transport cycle of the Na+/H+ antiporter NhaP from Pyrococcus abyssi. |
url |
https://doi.org/10.1038/s41467-019-09739-0 |
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