Relevance of Bcl-x expression in different types of endometrial tissues

• Main Authors: Li Yanxia, Zhao Yanhui, Ma Xiaoxin, Lu Hongwei, He Yuanqi
• Format: Article
• Language: English
• Published: BMC 2010-02-01
• Series: Journal of Experimental & Clinical Cancer Research
• Online Access: http://www.jeccr.com/content/29/1/14

<p>Abstract</p> <p>Objectives</p> <p>To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs.</p> <p>Methods</p> <p>RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types.</p> <p>Results</p> <p>The Bcl-xl expression levels of simple and atypical hyperplasia endometrial tissues were not significantly different from that of normal endometrial tissue (both <it>P </it>> 0.05). On contrary, Bcl-xl expression in endometrial carcinoma tissue was significantly higher than the normal endometrial tissue (<it>P </it>= 0.00), which was correlated with the pathological grading of endometrial carcinoma (F = 5.33, <it>P </it>= 0.02). In addition, Bcl-xs mRNA level in simple hyperplasia endometrial tissue had no significant difference compared to that in normal endometrial tissue (<it>P </it>= 0.12), while the levels of atypical hyperplasia and endometrial carcinoma endometrial tissues were significantly different from the normal endometrial tissue (both <it>P </it>= 0.00). Furthermore, level of Bcl-xs mRNA was correlated with the clinical staging and lymph node metastasis of the endometrial carcinoma (<it>P </it>< 0.05). The expressions of Bcl-xl and Bcl-xs were negatively correlated with each other (<it>r </it>= -0.76).</p> <p>Conclusion</p> <p>The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma.</p>