Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells

Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells

MicroRNAs (miRs) are one of the most important post-transcriptional repressors of gene expression. However, miR-574-5p has recently been shown to positively regulate the expression of microsomal prostaglandin E-synthase-1 (mPGES-1), a key enzyme in the prostaglandin E2 (PGE2) biosynthesis, by acting...

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Bibliographic Details
Main Authors: Anne C. Emmerich, Julia Wellstein, Elena Ossipova, Isabell Baumann, Johan Lengqvist, Kim Kultima, Per-Johan Jakobsson, Dieter Steinhilber, Meike J. Saul
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
miR-574-5p
CUGBP1
non-canonical miR function
decoy
proteomics
mPGES-1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00196/full

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