Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC- pathway and modulated by endogenous H2S

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC- pathway and modulated by endogenous H2S

Activation of plasma membrane TGR5 receptors in enteroendocrine cells by bile acids is known to regulate gastrointestinal secretion and motility and glucose homeostasis. The endocrine functions of the gut are modulated by microenvironment of the distal gut predominantly by sulfur-containing bacteria...

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Bibliographic Details
Main Authors: Vanitha eBala, Senthilkumar eRajagopal, Divya P Kumar, Ancy D Nalli, Sunila eMahavadi, Arun J Sanyal, John R Grider, Karnam eMurthy
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Physiology
Subjects:
Bile Acids and Salts
Enteroendocrine Cells
Hydrogen Sulfide
gastrointestinal peptides
Signaling Pathways
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00420/full

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