Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action

Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action

Polyphenols have been reported to have wide spectrum of biological activities including major impact on initiation, promotion, and progression of cancer by modulating different signalling pathways. Colorectal cancer is the second most major cause of mortality and morbidity among females and the thir...

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Main Authors: Md Nur Alam, Muhammad Almoyad, Fazlul Huq
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/4154185
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spelling doaj-d95ee478e2d0426eb43c3e02f74342db2020-11-24T21:31:52ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/41541854154185Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of ActionMd Nur Alam0Muhammad Almoyad1Fazlul Huq2Discipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus C42, East Street, Lidcombe, NSW 1825, AustraliaDiscipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus C42, East Street, Lidcombe, NSW 1825, AustraliaDiscipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus C42, East Street, Lidcombe, NSW 1825, AustraliaPolyphenols have been reported to have wide spectrum of biological activities including major impact on initiation, promotion, and progression of cancer by modulating different signalling pathways. Colorectal cancer is the second most major cause of mortality and morbidity among females and the third among males. The objective of this review is to describe the activity of a variety of polyphenols in colorectal cancer in clinical trials, preclinical studies, and primary research. The molecular mechanisms of major polyphenols related to their beneficial effects on colorectal cancer are also addressed. Synthetic modifications and other future directions towards exploiting of natural polyphenols against colorectal cancer are discussed in the last section.http://dx.doi.org/10.1155/2018/4154185
collection DOAJ
language English
format Article
sources DOAJ
author Md Nur Alam
Muhammad Almoyad
Fazlul Huq
spellingShingle Md Nur Alam
Muhammad Almoyad
Fazlul Huq
Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
BioMed Research International
author_facet Md Nur Alam
Muhammad Almoyad
Fazlul Huq
author_sort Md Nur Alam
title Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
title_short Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
title_full Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
title_fullStr Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
title_full_unstemmed Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
title_sort polyphenols in colorectal cancer: current state of knowledge including clinical trials and molecular mechanism of action
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2018-01-01
description Polyphenols have been reported to have wide spectrum of biological activities including major impact on initiation, promotion, and progression of cancer by modulating different signalling pathways. Colorectal cancer is the second most major cause of mortality and morbidity among females and the third among males. The objective of this review is to describe the activity of a variety of polyphenols in colorectal cancer in clinical trials, preclinical studies, and primary research. The molecular mechanisms of major polyphenols related to their beneficial effects on colorectal cancer are also addressed. Synthetic modifications and other future directions towards exploiting of natural polyphenols against colorectal cancer are discussed in the last section.
url http://dx.doi.org/10.1155/2018/4154185
work_keys_str_mv AT mdnuralam polyphenolsincolorectalcancercurrentstateofknowledgeincludingclinicaltrialsandmolecularmechanismofaction
AT muhammadalmoyad polyphenolsincolorectalcancercurrentstateofknowledgeincludingclinicaltrialsandmolecularmechanismofaction
AT fazlulhuq polyphenolsincolorectalcancercurrentstateofknowledgeincludingclinicaltrialsandmolecularmechanismofaction
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