Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma

Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma

Abstract Objectives Patients with laryngeal squamous cell carcinoma (LSCC) often fail radiation therapy (RT), when received as monotherapy or in combination with other treatment modalities. Mechanisms for RT failure are poorly understood. We hypothesized that tumors failing RT would have increased r...

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Bibliographic Details
Main Authors: Siddharth Sheth, Douglas R. Farquhar, Travis P. Schrank, Wesley Stepp, Angela Mazul, Michele Hayward, Nicholas Lenze, Paul Little, Heejoon Jo, M. Ben Major, Bhishamjit S. Chera, Jose P. Zevallos, D. Neil Hayes
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Laryngoscope Investigative Otolaryngology
Subjects:
laryngeal squamous cell carcinoma
oxidative stress
radiation resistance
Online Access:https://doi.org/10.1002/lio2.588

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