Long non-coding RNA TUG1 knockdown promotes autophagy and improves acute renal injury in ischemia-reperfusion-treated rats by binding to microRNA-29 to silence PTEN

Long non-coding RNA TUG1 knockdown promotes autophagy and improves acute renal injury in ischemia-reperfusion-treated rats by binding to microRNA-29 to silence PTEN

Abstract Objective Long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is increased under the condition of ischemia. This study intended to identify the mechanism of TUG1 in renal ischemia-reperfusion (I/R). Methods First, a rat model of acute renal injury induced by I/R was established, f...

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Bibliographic Details
Main Authors: Zhiquan Xu, Xiaoyan Huang, Qiuyu Lin, Wei Xiang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Nephrology
Subjects:
Renal ischemia-reperfusion
Autophagy
Apoptosis
Long noncoding RNA TUG1
PTEN
mcroRNA-29
Online Access:https://doi.org/10.1186/s12882-021-02473-0

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