Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation[S]

Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation[S]

The compound 20-HETE is involved in numerous physiological functions, including blood pressure and platelet aggregation. Glucuronidation of 20-HETE by UDP-glucuronosyltransferases (UGTs) is thought to be a primary pathway of 20-HETE elimination in humans. The present study identified major UGT enzym...

Full description

Bibliographic Details
Main Authors:	Yazun Bashir Jarrar, Eun-Young Cha, Kyung-Ah Seo, Jong-Lyul Ghim, Hyo-Ji Kim, Dong-Hyun Kim, Su-Jun Lee, Jae-Gook Shin
Format:	Article
Language:	English
Published:	Elsevier 2014-11-01
Series:	Journal of Lipid Research
Subjects:	20-hydroxyeicosatetraenoic acid uridine diphosphate-glucuronosyltransferase genetic polymorphisms arachidonic acid
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520349853

Similar Items

Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases
by: Joanna M. Little, et al.
Published: (2004-09-01)

Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola[S]
by: Inge Van Bogaert, et al.
Published: (2013-11-01)

Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases
by: Sang-Bum Kim, et al.
Published: (2019-02-01)

Inhibitory and Inductive Effects of <i>Opuntia ficus indica</i> Extract and Its Flavonoid Constituents on Cytochrome P450s and UDP-Glucuronosyltransferases
by: Hyesoo Jeong, et al.
Published: (2018-10-01)

Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes
by: Raju Khatri, et al.
Published: (2021-04-01)

Gilbert’s Syndrome: Terminology, Epidemiology, Genetics, Pathogenesis (Part I)
by: T.V. Sorokman, et al.
Published: (2016-11-01)

Identification, Characterization and Engineering of UDP-Glucuronosyltransferases for Synthesis of Flavonoid Glucuronides
by: Adiji, Olubu Adeoye
Published: (2020)

Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS
by: Liudmila L. Mazaleuskaya, et al.
Published: (2018-03-01)

Polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function
by: Webb, Catherine Marie
Published: (2014)

In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters
by: Sunjoo Kim, et al.
Published: (2020-10-01)

In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters
by: Sunjoo Kim, et al.
Published: (2019-08-01)

A broad-spectrum substrate for the human UDP-glucuronosyltransferases and its use for investigating glucuronidation inhibitors
by: Finel, M., et al.
Published: (2021)

Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro
by: Xia-Wen Liu, et al.
Published: (2018-01-01)

Expression, purification and characterization of rat UDP-glucuronosyltransferase 1A8.
Published: (2006)

Relation between Neonatal Icter and Gilbert Syndrome in Gloucose-6-Phosphate Dehydrogenase Deficient Subjects
by: Yadollah Zahedpasha, et al.
Published: (2014-03-01)

N–3 fatty acid deficiency in the rat pineal gland: effects on phospholipid molecular species composition and endogenous levels of melatonin and lipoxygenase products
by: Hongjian Zhang, et al.
Published: (1998-07-01)

In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes
by: Xiaodan Hong, et al.
Published: (2017-09-01)

Relationship between UGT1A1*6/*28 gene polymorphisms and the efficacy and toxicity of irinotecan-based chemotherapy
by: Bai Y, et al.
Published: (2017-06-01)

Study of the alterations of intestinal UDP-glucuronosyltransferases by gut dysbiosis in experimental colitis in the rat
by: Gao, Xue Jiao
Published: (2018)

Albumin modifies the metabolism of hydroxyeicosatetraenoic acids via 12-lipoxygenase in human platelets
by: Marina Dadaian, et al.
Published: (1999-05-01)

UDP-Glucuronosyltransferase Promoter Polymorphism in Iranian Neonates with Idiopathic Hyperbilirubinemia
by: Mahbod Kaveh, et al.
Published: (2013-11-01)

Age-dependent Hepatic UDP-glucuronosyltransferase Gene Expression and Activity in Children
by: Elizabeth Neumann, et al.
Published: (2016-11-01)

Oils’ Impact on Comprehensive Fatty Acid Analysis and Their Metabolites in Rats
by: Agnieszka Stawarska, et al.
Published: (2020-04-01)

Effects of over-expressing UDP-glucuronosyltransferase 1A1 on xenobiotic and therapeutic drug metabolism.
Published: (2006)

Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases
by: David Turgeon, et al.
Published: (2003-06-01)

Diagnosis of gilbert’s syndrome via pyrosequencing in clinical practice
by: L. I. Melnikova, et al.
Published: (2019-11-01)

Hereditary hyperbilirubinemias
by: Radlović Nedeljko
Published: (2014-01-01)

Regulation of 5-oxo-ETE synthesis by pyridine nucleotides in aging neutrophils
by: Graham, François.
Published: (2008)

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression
by: Delores J. Grant, et al.
Published: (2017-07-01)

Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases
by: Yiou Pan, et al.
Published: (2018-04-01)

Structure and protein-protein interactions of human UDP-glucuronosyltransferases
by: Ryoichi Fujiwara, et al.
Published: (2016-10-01)

Identification of Catalposide Metabolites in Human Liver and Intestinal Preparations and Characterization of the Relevant Sulfotransferase, UDP-glucuronosyltransferase, and Carboxylesterase Enzymes
by: Deok-Kyu Hwang, et al.
Published: (2019-07-01)

20-HETE inhibits the proliferation of vascular smooth muscle cells via transforming growth factor-β
by: Chan-Jung Liang, et al.
Published: (2008-01-01)

Uridinediphosphate-glucuronosyltransferase (UDP-GT) Ontogeny and PCB Effects in Galliform Birds
by: McCleary, Ryan J. R.
Published: (2014)

A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders[S]
by: Zhong-Ze Fang, et al.
Published: (2013-12-01)

Effect of UDP‐glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome
by: May‐Jen Huang, et al.
Published: (2019-07-01)

NUCLEOSIDE-DIPHOSPHATASE OF CESTODE BOTHRIOCEPHALUS SCORPII (CESTODA: BOTHRIOCEPHALIDAE)
by: E. A. Burenina
Published: (2016-12-01)

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication
by: Mohamed eOuzzine, et al.
Published: (2014-10-01)

Characterization of UDP-Glucuronosyltransferases and the Potential Contribution to Nicotine Tolerance in <i>Myzus persicae</i>
by: Yiou Pan, et al.
Published: (2019-07-01)

ASSESMENT OF PLTELET ANTIAGGREGANT ACTIVITY OF A FRACTION FROM AN ETHANOLIC EXTRACT OF THE BARK OF Nectandra amazonum Nees
by: Jenaro Antonio ESPITIA CORREDOR, et al.