Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05815-z |
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doaj-d950f5d4286b4fd19e6d199b06c153c52021-05-11T10:32:55ZengNature Publishing GroupNature Communications2041-17232018-08-019111310.1038/s41467-018-05815-zSystematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivityRyan S. Soderquist0Lorin Crawford1Esther Liu2Min Lu3Anika Agarwal4Grace R. Anderson5Kevin H. Lin6Peter S. Winter7Merve Cakir8Kris C. Wood9Department of Pharmacology and Cancer Biology, Duke UniversityDepartment of Statistics, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3 mimeticshttps://doi.org/10.1038/s41467-018-05815-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ryan S. Soderquist Lorin Crawford Esther Liu Min Lu Anika Agarwal Grace R. Anderson Kevin H. Lin Peter S. Winter Merve Cakir Kris C. Wood |
| spellingShingle |
Ryan S. Soderquist Lorin Crawford Esther Liu Min Lu Anika Agarwal Grace R. Anderson Kevin H. Lin Peter S. Winter Merve Cakir Kris C. Wood Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity Nature Communications |
| author_facet |
Ryan S. Soderquist Lorin Crawford Esther Liu Min Lu Anika Agarwal Grace R. Anderson Kevin H. Lin Peter S. Winter Merve Cakir Kris C. Wood |
| author_sort |
Ryan S. Soderquist |
| title |
Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity |
| title_short |
Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity |
| title_full |
Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity |
| title_fullStr |
Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity |
| title_full_unstemmed |
Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity |
| title_sort |
systematic mapping of bcl-2 gene dependencies in cancer reveals molecular determinants of bh3 mimetic sensitivity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3 mimetics |
| url |
https://doi.org/10.1038/s41467-018-05815-z |
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