Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy

Altered T-Lymphocyte Biology Following High-Dose Melphalan and Autologous Stem Cell Transplantation With Implications for Adoptive T-Cell Therapy

In relapsed and refractory multiple myeloma (MM), adoptive cell therapies (ACT) including CAR-T-cells are under clinical investigation. However, relapse due to T-cell exhaustion or limited persistence is an obstacle. Before ACT are considered in MM, high-dose (HD) melphalan followed by autologous st...

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Bibliographic Details
Main Authors: Thomas Mika, Swetlana Ladigan-Badura, Abdelouahid Maghnouj, Bakr Mustafa, Susanne Klein-Scory, Alexander Baraniskin, Sascha Döhring, Ilka Fuchs, Stephan Ehl, Stephan A. Hahn, Roland Schroers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
gene expression
lentiviral transduction
lymphocyte proliferation
chimeric antigen receptor
melphalan
multiple myeloma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.568056/full

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