A Novel Protocol Using Small-Scale Spray-Drying for the Efficient Screening of Solid Dispersions in Early Drug Development and Formulation, as a Straight Pathway from Screening to Manufacturing Stages

A Novel Protocol Using Small-Scale Spray-Drying for the Efficient Screening of Solid Dispersions in Early Drug Development and Formulation, as a Straight Pathway from Screening to Manufacturing Stages

This work describes a novel screening strategy that implements small-scale spray-drying in early development of binary amorphous solid dispersions (ASDs). The proposed methodology consists of a three-stage decision protocol in which small batches (20–100 mg) of spray-dried solid dispersion...

Full description

Bibliographic Details
Main Authors: Aymeric Ousset, Rosanna Chirico, Florent Robin, Martin Alexander Schubert, Pascal Somville, Kalliopi Dodou
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceuticals
Subjects:
amorphous solid dispersions
screening
spray-dryer
downscaling
polymers
miscibility
dissolution
supersaturation
stability
Online Access:http://www.mdpi.com/1424-8247/11/3/81

Internet

http://www.mdpi.com/1424-8247/11/3/81

Similar Items