Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis

Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis

Abstract Background Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and function damaged by chemotherapy. miR-21 is a microRNA that can regulate cel...

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Bibliographic Details
Main Authors: Xiafei Fu, Yuanli He, Xuefeng Wang, Dongxian Peng, Xiaoying Chen, Xinran Li, Qing Wang
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Stem Cell Research & Therapy
Subjects:
miR-21
Bone marrow derived mesenchymal stem cells
Chemotherapy-induced premature ovarian failure
Apoptosis
PTEN
PDCD4
Online Access:http://link.springer.com/article/10.1186/s13287-017-0641-z

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