Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia

Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia

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We report an extremely rare and complex case of a 44-year-old woman diagnosed with an early stage triple negative breast cancer in the setting of primary autoimmune neutropenia with a pre-existing severe neutropenia. This case-report demonstrates that adjuvant chemotherapy for breast cancer can be a...

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Main Authors: Michael Trus, Kavita Dhamanaskar, Jayson Potts, Parveen Wasi, Satvir Bains, Louise Bordeleau
Format: Article
Language:English
Published: SAGE Publishing 2013-01-01
Series:Breast Cancer: Basic and Clinical Research
Online Access:https://doi.org/10.4137/BCBCR.S10767
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spelling doaj-d929a7339b204baa86a17f0c593b3d592020-11-25T03:32:03ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342013-01-01710.4137/BCBCR.S10767Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune NeutropeniaMichael Trus0Kavita Dhamanaskar1Jayson Potts2Parveen Wasi3Satvir Bains4Louise Bordeleau5Juravinski Hospital, Hamilton, Ontario, Canada.Juravinski Hospital, Hamilton, Ontario, Canada.McMaster University, Hamilton, Ontario, Canada.McMaster University, Hamilton, Ontario, Canada.Juravinski Cancer Centre, Hamilton, Ontario, Canada.Juravinski Cancer Centre, Hamilton, Ontario, Canada.We report an extremely rare and complex case of a 44-year-old woman diagnosed with an early stage triple negative breast cancer in the setting of primary autoimmune neutropenia with a pre-existing severe neutropenia. This case-report demonstrates that adjuvant chemotherapy for breast cancer can be administered in a patient with severe neutropenia. The management is however complicated and requires careful monitoring of side-effects related to both chemotherapy and treatment of autoimmune neutropenia. The role of chemotherapy in the treatment of triple negative breast cancer, the approach to autoimmune neutropenia and potential interactions are reviewed. To our knowledge, this is the first case reporting on the use of chemotherapy in a patient with severe pre-existing primary autoimmune neutropenia.https://doi.org/10.4137/BCBCR.S10767
collection DOAJ
language English
format Article
sources DOAJ
author Michael Trus
Kavita Dhamanaskar
Jayson Potts
Parveen Wasi
Satvir Bains
Louise Bordeleau
spellingShingle Michael Trus
Kavita Dhamanaskar
Jayson Potts
Parveen Wasi
Satvir Bains
Louise Bordeleau
Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia
Breast Cancer: Basic and Clinical Research
author_facet Michael Trus
Kavita Dhamanaskar
Jayson Potts
Parveen Wasi
Satvir Bains
Louise Bordeleau
author_sort Michael Trus
title Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia
title_short Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia
title_full Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia
title_fullStr Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia
title_full_unstemmed Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia
title_sort adjuvant chemotherapy for breast cancer in a patient with primary autoimmune neutropenia
publisher SAGE Publishing
series Breast Cancer: Basic and Clinical Research
issn 1178-2234
publishDate 2013-01-01
description We report an extremely rare and complex case of a 44-year-old woman diagnosed with an early stage triple negative breast cancer in the setting of primary autoimmune neutropenia with a pre-existing severe neutropenia. This case-report demonstrates that adjuvant chemotherapy for breast cancer can be administered in a patient with severe neutropenia. The management is however complicated and requires careful monitoring of side-effects related to both chemotherapy and treatment of autoimmune neutropenia. The role of chemotherapy in the treatment of triple negative breast cancer, the approach to autoimmune neutropenia and potential interactions are reviewed. To our knowledge, this is the first case reporting on the use of chemotherapy in a patient with severe pre-existing primary autoimmune neutropenia.
url https://doi.org/10.4137/BCBCR.S10767
work_keys_str_mv AT michaeltrus adjuvantchemotherapyforbreastcancerinapatientwithprimaryautoimmuneneutropenia
AT kavitadhamanaskar adjuvantchemotherapyforbreastcancerinapatientwithprimaryautoimmuneneutropenia
AT jaysonpotts adjuvantchemotherapyforbreastcancerinapatientwithprimaryautoimmuneneutropenia
AT parveenwasi adjuvantchemotherapyforbreastcancerinapatientwithprimaryautoimmuneneutropenia
AT satvirbains adjuvantchemotherapyforbreastcancerinapatientwithprimaryautoimmuneneutropenia
AT louisebordeleau adjuvantchemotherapyforbreastcancerinapatientwithprimaryautoimmuneneutropenia
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