Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge.

Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge.

West Nile virus (WNV) is a mosquito-borne flavivirus that is endemic in Africa, the Middle East, Europe and the United States. There is currently no antiviral treatment or human vaccine available to treat or prevent WNV infection. DNA plasmid-based vaccines represent a new approach for controlling i...

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Bibliographic Details
Main Authors: Marina De Filette, Silke Soehle, Sebastian Ulbert, Justin Richner, Michael S Diamond, Alessandro Sinigaglia, Luisa Barzon, Stefan Roels, Julianna Lisziewicz, Orsolya Lorincz, Niek N Sanders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3913677?pdf=render

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