Downregulation of Epidermal Growth Factor Receptor Expression Contributes to α-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines

Downregulation of Epidermal Growth Factor Receptor Expression Contributes to α-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines

RRR-α-tocopherol derivative α-TEA (RRR-α-tocopherol ether-linked acetic acid analog) has been shown to be a potent antitumor agent both in vivo and in vitro. In this study, we investigated the effects of α-TEA on the expression of epidermal growth factor receptor (EGFR) family members, ErbB1, 2 and...

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Bibliographic Details
Main Authors: Ming-Chieh Shun, Weiping Yu, Sook-Kyung Park, Bob G. Sanders, Kimberly Kline
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2010/824571

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