GSK5182, 4-Hydroxytamoxifen Analog, a New Potential Therapeutic Drug for Osteoarthritis

GSK5182, 4-Hydroxytamoxifen Analog, a New Potential Therapeutic Drug for Osteoarthritis

Estrogen-related receptors (ERRs) are the first identified orphan nuclear receptors. The ERR family consists of ERRα, ERRβ, and ERRγ, regulating diverse isoform-specific functions. We have reported the importance of ERRγ in osteoarthritis (OA) pathogenesis. However, therapeutic approaches with ERRγ...

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Bibliographic Details
Main Authors: Yunhui Min, Dahye Kim, Godagama Gamaarachchige Dinesh Suminda, Xiangyu Zhao, Mangeun Kim, Yaping Zhao, Young-Ok Son
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
GSK5182
ERRγ
cartilage degeneration
osteoarthritis
Online Access:https://www.mdpi.com/1424-8247/13/12/429

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