Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.

Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.

The expression of focal adhesion kinase family interacting protein of 200-kDa (FIP200) in normal brain is limited to some neurons and glial cells. On immunohistochemical analysis of biopsies of glioblastoma tumors, we detected FIP200 in the tumor cells, tumor-associated endothelial cells, and occasi...

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Main Authors: Dongyan Wang, Mitchell A Olman, Jerry Stewart, Russell Tipps, Ping Huang, Paul W Sanders, Eric Toline, Richard A Prayson, Jeongwu Lee, Robert J Weil, Cheryl A Palmer, G Yancey Gillespie, Wei Michael Liu, Russell O Pieper, Jun-Lin Guan, Candece L Gladson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21602932/?tool=EBI

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