The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer

The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer

Abstract Background Approximately 30% of patients with epidermal growth factor receptor (EGFR)-activating mutations have no response to EGFR-tyrosine kinase inhibitors (TKIs) (primary resistance). However, little is known about the molecular mechanism involved in primary resistance to EGFR-TKIs in E...

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Bibliographic Details
Main Authors: Yang Zhang, Yuanyuan Zeng, Ting Liu, Wenwen Du, Jianjie Zhu, Zeyi Liu, Jian-an Huang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Respiratory Research
Subjects:
PD-L1
EGFR-TKI
Drug resistance
TGF-β/Smad signalling
NSCLC
Online Access:http://link.springer.com/article/10.1186/s12931-019-1137-4

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http://link.springer.com/article/10.1186/s12931-019-1137-4

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