Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.

There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs). We conducted this meta-analysis to investigate the association between prenatal alcohol exposure and the risk of overall CHDs and the CHDs subtypes.Case-control and cohor...

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Main Authors: Jiaomei Yang, Huizhen Qiu, Pengfei Qu, Ruo Zhang, Lingxia Zeng, Hong Yan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4482023?pdf=render
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spelling doaj-d90ed44041d94f17b77e037c7dfd34c82020-11-25T02:47:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013068110.1371/journal.pone.0130681Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.Jiaomei YangHuizhen QiuPengfei QuRuo ZhangLingxia ZengHong YanThere are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs). We conducted this meta-analysis to investigate the association between prenatal alcohol exposure and the risk of overall CHDs and the CHDs subtypes.Case-control and cohort studies published before March 2015 were searched through PubMed and Embase. Two authors independently extracted data and scored the study quality according to the Newcastle-0ttawa Scale. The pooled ORs and 95%CI were estimated using the random-effects model and heterogeneity was assessed by the Q test and I2 statistic.A total of 20 studies were finally included. The results provided no evidence of the association between prenatal alcohol exposure and the risk of overall CHDs (OR = 1.06, 95%CI = 0.93-1.22), ventricular septal defects (VSDs) (OR = 1.04, 95%CI = 0.86-1.25), or atrial septal defects (ASDs) (OR = 1.40, 95%CI = 0.88-2.23). However, prenatal alcohol drinking was marginally significantly associated with conotruncal defects (CTDs) (OR = 1.24, 95%CI = 0.97-1.59) and statistically significantly associated with d-Transposition of the Great Arteries (dTGA) (OR = 1.64, 95%CI = 1.17-2.30). Moreover, both prenatal heavy drinking and binge drinking have a strong association with overall CHDs (heavy drinking: OR = 3.76, 95%CI = 1.00-14.10; binge drinking: OR = 2.49, 95%CI = 1.04-5.97), and prenatal moderate drinking has a modest association with CTDs (OR = 1.35, 95%CI = 1.05-1.75) and dTGA (OR = 1.86, 95%CI = 1.09-3.20).In conclusion, the results suggested that prenatal alcohol exposure was not associated with overall CHDs or some subtypes, whereas marginally significant association was found for CTDs and statistically significant association was found for dTGA. Further prospective studies with large population and better designs are needed to explore the association of prenatal alcohol exposure with CHDs including the subtypes in specific groups.http://europepmc.org/articles/PMC4482023?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Jiaomei Yang
Huizhen Qiu
Pengfei Qu
Ruo Zhang
Lingxia Zeng
Hong Yan
spellingShingle Jiaomei Yang
Huizhen Qiu
Pengfei Qu
Ruo Zhang
Lingxia Zeng
Hong Yan
Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.
PLoS ONE
author_facet Jiaomei Yang
Huizhen Qiu
Pengfei Qu
Ruo Zhang
Lingxia Zeng
Hong Yan
author_sort Jiaomei Yang
title Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.
title_short Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.
title_full Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.
title_fullStr Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.
title_full_unstemmed Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.
title_sort prenatal alcohol exposure and congenital heart defects: a meta-analysis.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2015-01-01
description There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs). We conducted this meta-analysis to investigate the association between prenatal alcohol exposure and the risk of overall CHDs and the CHDs subtypes.Case-control and cohort studies published before March 2015 were searched through PubMed and Embase. Two authors independently extracted data and scored the study quality according to the Newcastle-0ttawa Scale. The pooled ORs and 95%CI were estimated using the random-effects model and heterogeneity was assessed by the Q test and I2 statistic.A total of 20 studies were finally included. The results provided no evidence of the association between prenatal alcohol exposure and the risk of overall CHDs (OR = 1.06, 95%CI = 0.93-1.22), ventricular septal defects (VSDs) (OR = 1.04, 95%CI = 0.86-1.25), or atrial septal defects (ASDs) (OR = 1.40, 95%CI = 0.88-2.23). However, prenatal alcohol drinking was marginally significantly associated with conotruncal defects (CTDs) (OR = 1.24, 95%CI = 0.97-1.59) and statistically significantly associated with d-Transposition of the Great Arteries (dTGA) (OR = 1.64, 95%CI = 1.17-2.30). Moreover, both prenatal heavy drinking and binge drinking have a strong association with overall CHDs (heavy drinking: OR = 3.76, 95%CI = 1.00-14.10; binge drinking: OR = 2.49, 95%CI = 1.04-5.97), and prenatal moderate drinking has a modest association with CTDs (OR = 1.35, 95%CI = 1.05-1.75) and dTGA (OR = 1.86, 95%CI = 1.09-3.20).In conclusion, the results suggested that prenatal alcohol exposure was not associated with overall CHDs or some subtypes, whereas marginally significant association was found for CTDs and statistically significant association was found for dTGA. Further prospective studies with large population and better designs are needed to explore the association of prenatal alcohol exposure with CHDs including the subtypes in specific groups.
url http://europepmc.org/articles/PMC4482023?pdf=render
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