Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum

Dysfunction at synapses is thought to be an early change contributing to cognitive, psychiatric and motor disturbances in Huntington’s disease (HD). In neurons, mutant Huntingtin collects in aggregates and distributes to the same sites as wild-type Huntingtin including on membranes and in synapses....

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Bibliographic Details
Main Authors: Maria Iuliano, Connor Seeley, Ellen Sapp, Erin L. Jones, Callie Martin, Xueyi Li, Marian DiFiglia, Kimberly B. Kegel-Gleason
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
cholesteryl ester
lipidomics
PIP2
synapse
neurotransmitter receptors
electron microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2021.618391/full

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