The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+T cells, thus driving skin inflammation.

Bibliographic Details
Main Authors: Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido-Nakahara, Ikuya Tsuge, Masutaka Furue, Yoshinori Fukui
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13946

Internet

https://doi.org/10.1038/ncomms13946

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