SAMHD1: a new insight into HIV-1 restriction in myeloid cells
<p>Abstract</p> <p>Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the...
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doaj-d8e703cd926943cab1f911ce2bfa240f2020-11-24T21:33:53ZengBMCRetrovirology1742-46902011-07-01815510.1186/1742-4690-8-55SAMHD1: a new insight into HIV-1 restriction in myeloid cellsWu LiSt Gelais Corine<p>Abstract</p> <p>Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 infection in myeloid-lineage cells. SAMHD1 functions as a myeloid-cell-specific HIV-1 restriction factor by inhibiting viral DNA synthesis. Here we discuss the implications of these findings in delineating the mechanisms of HIV-1 restriction in myeloid-lineage cells and the potential role of Vpx in lentiviral pathogenesis.</p> http://www.retrovirology.com/content/8/1/55 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wu Li St Gelais Corine |
spellingShingle |
Wu Li St Gelais Corine SAMHD1: a new insight into HIV-1 restriction in myeloid cells Retrovirology |
author_facet |
Wu Li St Gelais Corine |
author_sort |
Wu Li |
title |
SAMHD1: a new insight into HIV-1 restriction in myeloid cells |
title_short |
SAMHD1: a new insight into HIV-1 restriction in myeloid cells |
title_full |
SAMHD1: a new insight into HIV-1 restriction in myeloid cells |
title_fullStr |
SAMHD1: a new insight into HIV-1 restriction in myeloid cells |
title_full_unstemmed |
SAMHD1: a new insight into HIV-1 restriction in myeloid cells |
title_sort |
samhd1: a new insight into hiv-1 restriction in myeloid cells |
publisher |
BMC |
series |
Retrovirology |
issn |
1742-4690 |
publishDate |
2011-07-01 |
description |
<p>Abstract</p> <p>Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 infection in myeloid-lineage cells. SAMHD1 functions as a myeloid-cell-specific HIV-1 restriction factor by inhibiting viral DNA synthesis. Here we discuss the implications of these findings in delineating the mechanisms of HIV-1 restriction in myeloid-lineage cells and the potential role of Vpx in lentiviral pathogenesis.</p> |
url |
http://www.retrovirology.com/content/8/1/55 |
work_keys_str_mv |
AT wuli samhd1anewinsightintohiv1restrictioninmyeloidcells AT stgelaiscorine samhd1anewinsightintohiv1restrictioninmyeloidcells |
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