SAMHD1: a new insight into HIV-1 restriction in myeloid cells

<p>Abstract</p> <p>Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the...

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Main Authors: Wu Li, St Gelais Corine
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/8/1/55
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spelling doaj-d8e703cd926943cab1f911ce2bfa240f2020-11-24T21:33:53ZengBMCRetrovirology1742-46902011-07-01815510.1186/1742-4690-8-55SAMHD1: a new insight into HIV-1 restriction in myeloid cellsWu LiSt Gelais Corine<p>Abstract</p> <p>Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 infection in myeloid-lineage cells. SAMHD1 functions as a myeloid-cell-specific HIV-1 restriction factor by inhibiting viral DNA synthesis. Here we discuss the implications of these findings in delineating the mechanisms of HIV-1 restriction in myeloid-lineage cells and the potential role of Vpx in lentiviral pathogenesis.</p> http://www.retrovirology.com/content/8/1/55
collection DOAJ
language English
format Article
sources DOAJ
author Wu Li
St Gelais Corine
spellingShingle Wu Li
St Gelais Corine
SAMHD1: a new insight into HIV-1 restriction in myeloid cells
Retrovirology
author_facet Wu Li
St Gelais Corine
author_sort Wu Li
title SAMHD1: a new insight into HIV-1 restriction in myeloid cells
title_short SAMHD1: a new insight into HIV-1 restriction in myeloid cells
title_full SAMHD1: a new insight into HIV-1 restriction in myeloid cells
title_fullStr SAMHD1: a new insight into HIV-1 restriction in myeloid cells
title_full_unstemmed SAMHD1: a new insight into HIV-1 restriction in myeloid cells
title_sort samhd1: a new insight into hiv-1 restriction in myeloid cells
publisher BMC
series Retrovirology
issn 1742-4690
publishDate 2011-07-01
description <p>Abstract</p> <p>Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of a putative restriction factor. Two recent studies discovered the cellular protein SAMHD1 to be this restriction factor, demonstrating that Vpx induces proteasomal degradation of SAMHD1 and enhances HIV-1 infection in myeloid-lineage cells. SAMHD1 functions as a myeloid-cell-specific HIV-1 restriction factor by inhibiting viral DNA synthesis. Here we discuss the implications of these findings in delineating the mechanisms of HIV-1 restriction in myeloid-lineage cells and the potential role of Vpx in lentiviral pathogenesis.</p>
url http://www.retrovirology.com/content/8/1/55
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