Metformin Attenuates Renal Fibrosis in a Mouse Model of Adenine-Induced Renal Injury Through Inhibiting TGF-β1 Signaling Pathways

Metformin Attenuates Renal Fibrosis in a Mouse Model of Adenine-Induced Renal Injury Through Inhibiting TGF-β1 Signaling Pathways

It is well-known that all progressive chronic kidney disease (CKD) is pathologically characterized by tubulointerstitial fibrosis process. Multiple studies have shown the critical role of inflammation and fibrosis in the development of CKD. Hence strategies that target inflammatory and fibrotic sign...

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Bibliographic Details
Main Authors: Hao Yi, Chunling Huang, Ying Shi, Qinghua Cao, Jason Chen, Xin-Ming Chen, Carol A. Pollock
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
metformin
renal fibrosis
adenine-induced renal injury
transforming growth factor β1 signaling pathways
animal model
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.603802/full

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