The Evolution and Diversity of Interleukin-17 Highlight an Expansion in Marine Invertebrates and Its Conserved Role in Mucosal Immunity

The Evolution and Diversity of Interleukin-17 Highlight an Expansion in Marine Invertebrates and Its Conserved Role in Mucosal Immunity

The interleukin-17 (IL-17) family consists of proinflammatory cytokines conserved during evolution. A comparative genomics approach was applied to examine IL-17 throughout evolution from poriferans to higher vertebrates. Cnidaria was highlighted as the most ancient diverged phylum, and several evolu...

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Bibliographic Details
Main Authors: Amaro Saco, Magalí Rey-Campos, Umberto Rosani, Beatriz Novoa, Antonio Figueras
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
interleukin
IL-17
comparative genomics
mucosal immunity
evolution
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.692997/full

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