Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide

Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide

Abstract Background Self-renewal and differentiation of embryonic stem cells (ESCs) is directed by biological and/or physical cues that regulate multiple signaling cascades. We have previously shown that mESCs seeded in a type I collagen matrix demonstrate a loss of pluripotent marker expression and...

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Bibliographic Details
Main Authors: Olesja Hazenbiller, Neil A. Duncan, Roman J. Krawetz
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Cell Biology
Subjects:
Embryonic stem cell
Collagen type I
Cyclic RGD peptide
Confined compression
Integrins
Mechano-transduction
Online Access:http://link.springer.com/article/10.1186/s12860-017-0148-6

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http://link.springer.com/article/10.1186/s12860-017-0148-6

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