Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunologic...

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Main Authors: Ieva Saulite, Wolfram Hoetzenecker, Stephan Weidinger, Antonio Cozzio, Emmanuella Guenova, Ulrike Wehkamp
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2016/9717530
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spelling doaj-d8c79615f4494be6a7c406bd0b1b25d62020-11-24T23:05:08ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/97175309717530Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and TargetsIeva Saulite0Wolfram Hoetzenecker1Stephan Weidinger2Antonio Cozzio3Emmanuella Guenova4Ulrike Wehkamp5Department of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse 31, 8091 Zurich, SwitzerlandDepartment of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse 31, 8091 Zurich, SwitzerlandDepartment of Dermatology, Christian-Albrechts-University Kiel, Kiel, GermanyDepartment of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse 31, 8091 Zurich, SwitzerlandDepartment of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse 31, 8091 Zurich, SwitzerlandDepartment of Dermatology, Christian-Albrechts-University Kiel, Kiel, GermanySézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.http://dx.doi.org/10.1155/2016/9717530
collection DOAJ
language English
format Article
sources DOAJ
author Ieva Saulite
Wolfram Hoetzenecker
Stephan Weidinger
Antonio Cozzio
Emmanuella Guenova
Ulrike Wehkamp
spellingShingle Ieva Saulite
Wolfram Hoetzenecker
Stephan Weidinger
Antonio Cozzio
Emmanuella Guenova
Ulrike Wehkamp
Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
BioMed Research International
author_facet Ieva Saulite
Wolfram Hoetzenecker
Stephan Weidinger
Antonio Cozzio
Emmanuella Guenova
Ulrike Wehkamp
author_sort Ieva Saulite
title Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_short Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_full Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_fullStr Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_full_unstemmed Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets
title_sort sézary syndrome and atopic dermatitis: comparison of immunological aspects and targets
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2016-01-01
description Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.
url http://dx.doi.org/10.1155/2016/9717530
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AT stephanweidinger sezarysyndromeandatopicdermatitiscomparisonofimmunologicalaspectsandtargets
AT antoniocozzio sezarysyndromeandatopicdermatitiscomparisonofimmunologicalaspectsandtargets
AT emmanuellaguenova sezarysyndromeandatopicdermatitiscomparisonofimmunologicalaspectsandtargets
AT ulrikewehkamp sezarysyndromeandatopicdermatitiscomparisonofimmunologicalaspectsandtargets
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