Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event

Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event

Synovial sarcoma is a tumor commonly involves extremities and periarticular soft tissue of young adults. Head and neck region is involved in 10% of cases, mostly biphasic in histology. Submandibular gland is an uncommon anatomic location for primary synovial sarcoma. Herein, we present a unique case...

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Main Authors: Afnan Elsayed, Haneen Al-Maghrabi, Hosam Alardati, Ameen Alherabi, Abdelrazak Meliti
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Human Pathology: Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214330019300239
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spelling doaj-d8bd44f371f54c3a9e5da49d7c32e2472020-11-24T21:30:55ZengElsevierHuman Pathology: Case Reports2214-33002019-09-0117Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare eventAfnan Elsayed0Haneen Al-Maghrabi1Hosam Alardati2Ameen Alherabi3Abdelrazak Meliti4Department of Anatomic Pathology, King Faisal Specialist Hospital and Research Centre- Jeddah, Saudi ArabiaDepartment of Anatomic Pathology, King Faisal Specialist Hospital and Research Centre- Jeddah, Saudi ArabiaDepartment of Anatomic Pathology, King Faisal Specialist Hospital and Research Centre- Jeddah, Saudi ArabiaDepartment of Anatomic Pathology, King Faisal Specialist Hospital and Research Centre- Jeddah, Saudi Arabia; Department of Surgery, Otolaryngology-Head & Neck Section, King Faisal Specialist Hospital, Research Centre- Jeddah, Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Anatomic Pathology, King Faisal Specialist Hospital and Research Centre- Jeddah, Saudi Arabia; Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, Alberta, Canada; Corresponding author at: King Faisal Specialist Hospital and Research Centre-Jeddah, Saudi Arabia and department of Laboratory Medicine and Pathology, University of Alberta, Canada.Synovial sarcoma is a tumor commonly involves extremities and periarticular soft tissue of young adults. Head and neck region is involved in 10% of cases, mostly biphasic in histology. Submandibular gland is an uncommon anatomic location for primary synovial sarcoma. Herein, we present a unique case of primary submandibular gland synovial sarcoma morphologically mimicking a solitary fibrous tumor. Moreover, the neoplastic cells reveal an aberrant p63 nuclear expression. The immunoprofile and the molecular studies confirmed TLE1 expression and SYT (18-11.2) rearrangement, respectively. To the best of our knowledge, the present case is the first with a p63 expression and the second reported case of primary submandibular gland synovial sarcoma in English literature. Keywords: Synovial sarcoma, submandibular gland, aberrant p63 expressionhttp://www.sciencedirect.com/science/article/pii/S2214330019300239
collection DOAJ
language English
format Article
sources DOAJ
author Afnan Elsayed
Haneen Al-Maghrabi
Hosam Alardati
Ameen Alherabi
Abdelrazak Meliti
spellingShingle Afnan Elsayed
Haneen Al-Maghrabi
Hosam Alardati
Ameen Alherabi
Abdelrazak Meliti
Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
Human Pathology: Case Reports
author_facet Afnan Elsayed
Haneen Al-Maghrabi
Hosam Alardati
Ameen Alherabi
Abdelrazak Meliti
author_sort Afnan Elsayed
title Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
title_short Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
title_full Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
title_fullStr Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
title_full_unstemmed Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
title_sort synovial sarcoma of submandibular gland with aberrant p63 expression a case report of rare event
publisher Elsevier
series Human Pathology: Case Reports
issn 2214-3300
publishDate 2019-09-01
description Synovial sarcoma is a tumor commonly involves extremities and periarticular soft tissue of young adults. Head and neck region is involved in 10% of cases, mostly biphasic in histology. Submandibular gland is an uncommon anatomic location for primary synovial sarcoma. Herein, we present a unique case of primary submandibular gland synovial sarcoma morphologically mimicking a solitary fibrous tumor. Moreover, the neoplastic cells reveal an aberrant p63 nuclear expression. The immunoprofile and the molecular studies confirmed TLE1 expression and SYT (18-11.2) rearrangement, respectively. To the best of our knowledge, the present case is the first with a p63 expression and the second reported case of primary submandibular gland synovial sarcoma in English literature. Keywords: Synovial sarcoma, submandibular gland, aberrant p63 expression
url http://www.sciencedirect.com/science/article/pii/S2214330019300239
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