A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development

A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development

Paracrine signaling in the tissue microenvironment is a central mediator of morphogenesis, and modeling this dynamic intercellular activity in vitro is critical to understanding normal and abnormal development. For example, Sonic Hedgehog (Shh) signaling is a conserved mechanism involved in multiple...

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Bibliographic Details
Main Authors:	Brian P. Johnson, Ross A. Vitek, Molly M. Morgan, Dustin M. Fink, Tyler G. Beames, Peter G. Geiger, David J. Beebe, Robert J. Lipinski
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	gene environment interaction chemical screening paracrine signaling cleft lip and palate embryonic morphogenesis epithelial mesenchymal cross-talk
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.621442/full

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