Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber

Abstract We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour mode...

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Main Authors:	Nurhaslina Hasan, Nur Fatihah Ronny Sham, Muhammad Khalis Abdul Karim, Syed Baharom Syed Ahmad Fuad, Narimah Abdul Hamid Hasani, Effat Omar, Mohammad Johari Ibahim
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-93964-5

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spelling	doaj-d8b27a3ac16045e485f79ca42c49abdb2021-07-18T11:27:43ZengNature Publishing GroupScientific Reports2045-23222021-07-011111710.1038/s41598-021-93964-5Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamberNurhaslina Hasan0Nur Fatihah Ronny Sham1Muhammad Khalis Abdul Karim2Syed Baharom Syed Ahmad Fuad3Narimah Abdul Hamid Hasani4Effat Omar5Mohammad Johari Ibahim6Faculty of Medicine, Universiti Teknologi MARAFaculty of Medicine, Universiti Teknologi MARAFaculty of Science, Universiti Putra MalaysiaFaculty of Medicine, Universiti Teknologi MARAFaculty of Medicine, Universiti Teknologi MARAFaculty of Medicine, Universiti Teknologi MARAFaculty of Medicine, Universiti Teknologi MARAAbstract We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites.https://doi.org/10.1038/s41598-021-93964-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nurhaslina Hasan Nur Fatihah Ronny Sham Muhammad Khalis Abdul Karim Syed Baharom Syed Ahmad Fuad Narimah Abdul Hamid Hasani Effat Omar Mohammad Johari Ibahim
spellingShingle	Nurhaslina Hasan Nur Fatihah Ronny Sham Muhammad Khalis Abdul Karim Syed Baharom Syed Ahmad Fuad Narimah Abdul Hamid Hasani Effat Omar Mohammad Johari Ibahim Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber Scientific Reports
author_facet	Nurhaslina Hasan Nur Fatihah Ronny Sham Muhammad Khalis Abdul Karim Syed Baharom Syed Ahmad Fuad Narimah Abdul Hamid Hasani Effat Omar Mohammad Johari Ibahim
author_sort	Nurhaslina Hasan
title	Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber
title_short	Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber
title_full	Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber
title_fullStr	Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber
title_full_unstemmed	Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber
title_sort	development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber
publisher	Nature Publishing Group
series	Scientific Reports
issn	2045-2322
publishDate	2021-07-01
description	Abstract We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites.
url	https://doi.org/10.1038/s41598-021-93964-5
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Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber

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