The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis

The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis

Since the surface immunogenic protein (Sip) of group B streptococcus was identified, it's immunogenicity and its potential as a universal vaccine candidate has been evaluated extensively. We developed recombinant Sip protein and used it for monoclonal antibody generation to develop immunochroma...

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Main Authors: Shiliang Cheng, Jiae Han, Yidan Huang, Qin Yan, Gang Lu, Zuowei Yuan, Guanjun Huang, Jian Zheng, Tianqiang Liu
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Heliyon
Subjects:
Microbiology
Immunology
Biochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018367835
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spelling doaj-d8ae85b4373f4595a1391b7c523a2e232020-11-25T02:20:02ZengElsevierHeliyon2405-84402019-06-0156e01899The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosisShiliang Cheng0Jiae Han1Yidan Huang2Qin Yan3Gang Lu4Zuowei Yuan5Guanjun Huang6Jian Zheng7Tianqiang Liu8Clinical Laboratory (QILU Clinical Laboratory), Shandong Provincial Third Hospital, Ji'nan, Shandong, 250031, ChinaClinical Laboratory, The People Hospital of Tianqiao District of Jinan, Shandong, 250031, ChinaArtron BioResearch Inc., Burnaby, British Columbia, V5J 5H6, CanadaArtron BioResearch Inc., Burnaby, British Columbia, V5J 5H6, CanadaArtron BioResearch Inc., Burnaby, British Columbia, V5J 5H6, CanadaArtron BioResearch Inc., Burnaby, British Columbia, V5J 5H6, CanadaNational and Local Joint Engineering Laboratory for Aquaculture Animal Disease Prevention and Control Technology, Chengdu, Sichuan, 610081, ChinaJinan Kangbo Biotechnology, 2766 Ying Xiu Road, Ji'nan, Shandong, 250101, China; Corresponding author.National and Local Joint Engineering Laboratory for Aquaculture Animal Disease Prevention and Control Technology, Chengdu, Sichuan, 610081, ChinaSince the surface immunogenic protein (Sip) of group B streptococcus was identified, it's immunogenicity and its potential as a universal vaccine candidate has been evaluated extensively. We developed recombinant Sip protein and used it for monoclonal antibody generation to develop immunochromatographic test kit for GBS detection. The test of bacteria and culture media revealed the correlation between Sip protein expression and diagnosis discrepancy, which has never been reported. Furthermore, not only the surface accessibility of the Sip protein may vary from strains or serotypes; the secretion level of Sip protein may also vary.http://www.sciencedirect.com/science/article/pii/S2405844018367835MicrobiologyImmunologyBiochemistry
collection DOAJ
language English
format Article
sources DOAJ
author Shiliang Cheng
Jiae Han
Yidan Huang
Qin Yan
Gang Lu
Zuowei Yuan
Guanjun Huang
Jian Zheng
Tianqiang Liu
spellingShingle Shiliang Cheng
Jiae Han
Yidan Huang
Qin Yan
Gang Lu
Zuowei Yuan
Guanjun Huang
Jian Zheng
Tianqiang Liu
The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
Heliyon
Microbiology
Immunology
Biochemistry
author_facet Shiliang Cheng
Jiae Han
Yidan Huang
Qin Yan
Gang Lu
Zuowei Yuan
Guanjun Huang
Jian Zheng
Tianqiang Liu
author_sort Shiliang Cheng
title The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_short The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_full The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_fullStr The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_full_unstemmed The correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
title_sort correlation between expression of sip protein in different serotypes of group b streptococcus and diagnosis
publisher Elsevier
series Heliyon
issn 2405-8440
publishDate 2019-06-01
description Since the surface immunogenic protein (Sip) of group B streptococcus was identified, it's immunogenicity and its potential as a universal vaccine candidate has been evaluated extensively. We developed recombinant Sip protein and used it for monoclonal antibody generation to develop immunochromatographic test kit for GBS detection. The test of bacteria and culture media revealed the correlation between Sip protein expression and diagnosis discrepancy, which has never been reported. Furthermore, not only the surface accessibility of the Sip protein may vary from strains or serotypes; the secretion level of Sip protein may also vary.
topic Microbiology
Immunology
Biochemistry
url http://www.sciencedirect.com/science/article/pii/S2405844018367835
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