Extrinsic and intrinsic regulation of axon regeneration at a crossroads

Extrinsic and intrinsic regulation of axon regeneration at a crossroads

Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosis, myelin debris and scar tissue that characterize the damaged CNS. Improved axon regeneration and r...

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Bibliographic Details
Main Authors: Andrew eKaplan, Stephan eOng Tone, Alyson eFournier
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal cord injury
RhoA
cAMP
conditioning lesion
PNS
CNS regeneration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00027/full

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