Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow

Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow

Background: Besides long-term trans-differentiation into neural cells, benefits of stem cell therapy (SCT) in ischemic stroke may include secretion of protective factors, which partly reflects extracellular vesicle (EVs) released by stem cell. However, the mechanism(s) by which stem cells/EVs limit...

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Bibliographic Details
Main Authors: Mansoureh Barzegar, Yuping Wang, Randa S. Eshaq, J. Winny Yun, Christen J. Boyer, Sergio G. Cananzi, Luke A. White, Oleg Chernyshev, Roger E. Kelley, Alireza Minagar, Karen Y. Stokes, Xiao-Hong Lu, Jonathan S. Alexander
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:EBioMedicine
Subjects:
Ischemic stroke
Human placental mesenchymal stem cells
Extracellular vesicles
Cerebral blood flow
Infarction
Blood brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420305375

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http://www.sciencedirect.com/science/article/pii/S2352396420305375

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