MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation

MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation

Myeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in several abnormal physiological conditions such as cancer. Recently, novel regulatory tumor MDSC biology modulating mechanisms, including differentiation, expansion and function, were defined....

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Main Authors: Elham Safarzadeh, Zahra Asadzadeh, Sahar Safaei, Arash Hatefi, Afshin Derakhshani, Francesco Giovannelli, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
cancer
miRNA
tumor microenvironment
long non-coding RNAs
molecular mechanism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.572323/full
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spelling doaj-d89baf49f3934e928612d634d54eb01b2020-11-25T03:28:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.572323572323MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells RegulationElham Safarzadeh0Elham Safarzadeh1Zahra Asadzadeh2Sahar Safaei3Arash Hatefi4Afshin Derakhshani5Afshin Derakhshani6Francesco Giovannelli7Oronzo Brunetti8Nicola Silvestris9Nicola Silvestris10Behzad Baradaran11Behzad Baradaran12Department of Microbiology & Immunology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, United StatesImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranMedical Oncology Unit—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori “Giovanni Paolo II” of Bari, Bari, ItalyMedical Oncology Unit—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori “Giovanni Paolo II” of Bari, Bari, ItalyMedical Oncology Unit—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori “Giovanni Paolo II” of Bari, Bari, ItalyMedical Oncology Unit—Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Tumori “Giovanni Paolo II” of Bari, Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, Department of Internal Medicine and Oncology (DIMO)—University of Bari, Bari, ItalyImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranMyeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in several abnormal physiological conditions such as cancer. Recently, novel regulatory tumor MDSC biology modulating mechanisms, including differentiation, expansion and function, were defined. There is growing evidence that miRNAs and long non-coding RNAs (lncRNA) are involved in modulating transcriptional factors to become complex regulatory networks that regulate the MDSCs in the tumor microenvironment. It is possible that aberrant expression of miRNAs and lncRNA contributes to MDSC biological characteristics under pathophysiological conditions. This review provides an overview on miRNAs and lncRNAs epiregulation of MDSCs development and immunosuppressive functions in cancer.https://www.frontiersin.org/article/10.3389/fimmu.2020.572323/fullmyeloid-derived suppressor cellscancermiRNAtumor microenvironmentlong non-coding RNAsmolecular mechanism
collection DOAJ
language English
format Article
sources DOAJ
author Elham Safarzadeh
Elham Safarzadeh
Zahra Asadzadeh
Sahar Safaei
Arash Hatefi
Afshin Derakhshani
Afshin Derakhshani
Francesco Giovannelli
Oronzo Brunetti
Nicola Silvestris
Nicola Silvestris
Behzad Baradaran
Behzad Baradaran
spellingShingle Elham Safarzadeh
Elham Safarzadeh
Zahra Asadzadeh
Sahar Safaei
Arash Hatefi
Afshin Derakhshani
Afshin Derakhshani
Francesco Giovannelli
Oronzo Brunetti
Nicola Silvestris
Nicola Silvestris
Behzad Baradaran
Behzad Baradaran
MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation
Frontiers in Immunology
myeloid-derived suppressor cells
cancer
miRNA
tumor microenvironment
long non-coding RNAs
molecular mechanism
author_facet Elham Safarzadeh
Elham Safarzadeh
Zahra Asadzadeh
Sahar Safaei
Arash Hatefi
Afshin Derakhshani
Afshin Derakhshani
Francesco Giovannelli
Oronzo Brunetti
Nicola Silvestris
Nicola Silvestris
Behzad Baradaran
Behzad Baradaran
author_sort Elham Safarzadeh
title MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation
title_short MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation
title_full MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation
title_fullStr MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation
title_full_unstemmed MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation
title_sort micrornas and lncrnas—a new layer of myeloid-derived suppressor cells regulation
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2020-10-01
description Myeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in several abnormal physiological conditions such as cancer. Recently, novel regulatory tumor MDSC biology modulating mechanisms, including differentiation, expansion and function, were defined. There is growing evidence that miRNAs and long non-coding RNAs (lncRNA) are involved in modulating transcriptional factors to become complex regulatory networks that regulate the MDSCs in the tumor microenvironment. It is possible that aberrant expression of miRNAs and lncRNA contributes to MDSC biological characteristics under pathophysiological conditions. This review provides an overview on miRNAs and lncRNAs epiregulation of MDSCs development and immunosuppressive functions in cancer.
topic myeloid-derived suppressor cells
cancer
miRNA
tumor microenvironment
long non-coding RNAs
molecular mechanism
url https://www.frontiersin.org/article/10.3389/fimmu.2020.572323/full
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