Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiencyResearch in context

Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiencyResearch in context

Background: TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage pathway. Deficiency of TK2 activity causes mitochondrial DNA (mtDNA) depletion, which in humans manifests predominantly as a mitochondrial m...

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Bibliographic Details
Main Authors:	Carlos Lopez-Gomez, Henly Hewan, Carlos Sierra, Hasan O. Akman, Maria J. Sanchez-Quintero, Marti Juanola-Falgarona, Saba Tadesse, Kurenai Tanji, Elisa E. Konofagou, Michio Hirano
Format:	Article
Language:	English
Published:	Elsevier 2019-08-01
Series:	EBioMedicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396419304797

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